Publication
- Isaac F. Lopez-Moyado#, Myunggon Ko#, Patrick G. Hogan, Anjana Rao. TET enzymes in the immune system: from DNA demethylation to immunotherapy, inflammation, and Cancer. (2024) Ann. Rev. Immunol. 42:455-88 (#co-1st) [PMID: 38360546]
- Hyejin Kim, Inkyung Jung, Chan Hyeong Lee, Jungeun An, Myunggon Ko. Development of Novel Epigenetic Anti-Cancer Therapy Targeting TET Proteins. (2023) Int. J. Mol. Sci. 24(22), 16375 [PMID: 38003566]
- Jungeun An and Myunggon Ko. Editorial for the Special Issue "Molecular Mechanisms of Leukemia" (2023) Int. J. Mol. Sci. 24(18):13936.
- Jun Liu, Suji Min, Dongchan Kim, Jihyun Park, Eunchae Park, Shanshan Pei, Youngil Koh, Dong-Yeop Shin, Ja Min Byun, Myunggon Ko, Sung-Soo Yoon, Junshik Hong. Pharmacological GLUT3 salvage augments the efficacy of vitamin C-induced TET2 restoration in acute myeloid leukemia. (2023) Leukemia, 37:1638. [PMID: 37393342]
- Habibulla Imran#, Jungeun An#, Kyumin Jang#, Asrar Alam, Venkataraman Dharuman*, Myunggon Ko**, Sooman Lim*. Highly selective and real-time detection of 5-hydroxymethylcytosine in genomic DNA using a carbon nitride-modified gold transducer-based electrochemical sensor. (2023), Journal of Alloys and Compounds 948: 1697145 (#co-1st, *co-corresponding)
- Inkyung Jung, Jungeun An*, Myunggon Ko*. Epigenetic regulators of DNA cytosine modification: Promising targets for cancer therapy (2023) Biomedicines 11:645. (*co-corresponding) [PMID: 36979633]
- Hiroshi Yuita#, Isaac F. López-Moyado#, Hyeongmin Jeong#, Arthur Xiuyuan Cheng, James Scott-Browne, Jungeun An, Toshinori Nakayama, Atsushi Onodera*, Myunggon Ko*, and Anjana Rao*. Inducible disruption of Tet genes results in myeloid malignancy, readthrough transcription, and a heterochromatin-to-euchromatin switch (2023) Proc. Natl. Acad. Sci. USA 120 (6) e2214824120 (#co-1st, *co-corresponding) [PMID: 37406303]
-Jungeun An and Myunggon Ko. Epigenetic modification of cytosines in hematopoietic differentiation and malignant transformation (2023) Int. J. Mol. Sci. 24(2):1727 [PMID: 36675240]
- Seongjun Byun#, Chan Hyeong Lee#, Hyeongmin Jeong#, Hyejin Kim, Hyug Moo Kwon, Sungho Park, Kyungjae Myung, Jungeun An*, Myunggon Ko*. Loss of adipose TET proteins enhances β-adrenergic responses and protects against obesity by epigenetic regulation of β3-AR expression. (2022) Proc. Natl. Acad. Sci. USA 119 (26) e2205626119 (#co-1st, *co-corresponding) [PMID: 35737830]
- Jinguk Jeong, Inkyung Jung, Ji-Hoon Kim, Shin Jeon, Do Young Hyeon, Hyungyu Min Byeonggeun Kang, Jinwoo Nah, Daehee Hwang, Soo-Jong Um, Myunggon Ko*, and Rho Hyun Seong*. BAP1 shapes the bone marrow niche for lymphopoiesis by fine-tuning epigenetic profiles in endosteal mesenchymal stromal cells. (2022) Cell Death & Differentiation 29(11):2151-2162 [PMID: 35473985] (*co-corresponding)
- Kiesar Sideeq Bhat#, Seongjun Byun#, Asrar Alam, Myunggon Ko*, Jungeun An*, Sooman Lim*. A fast and label-free detection of hydroxymethylated DNA using a nozzle-jet printed AuNPs@Ti3C2 MXene-based electrochemical sensor. (2022) Talanta 244: 123421 [PMID: 35397322] (#co-1st, *co-corresponding)
- Bhat, Kiesar Sideeq#, Kim, Hyejin#, Alam, Asrar, Ko, Myunggon*, An, Jungeun*, Lim, Sooman*. (2021). Rapid and Label-Free Detection of 5-Hydroxymethylcytosine in Genomic DNA Using an Au/ZnO Nanorods Hybrid Nanostructure-Based Electrochemical Sensor. Adv. Healthcare Mater. 10(22):e2101193 [PMID: 34558229]. (#co-1st, *co-corresponding)
- Seo Yeon Lee, Xue Qi, Myunggon Ko, Chan Hee Park, Jungeun An*, Sooman Lim*. (2020). Direct and rapid detection of 5-hydroxymethylcytosine, a novel cancer hallmark in DNA, using electrochemical reaction. Mat. Today Comm. v.25, pp.101399.
- Jungeun An, Myunggon Ko. (2020). Decoding ribosomes to keep growing (in AML). Blood 135 (23):2015-2016.
- Jungeun An, Anjana Rao, Myunggon Ko. (2017). TET family dioxygenases and DNA demethylation in stem cells and cancers. Exp. Mol. Med. 49(4):e323 [PMID: 28450733]
- Nair VS, Song MH, Ko M, Oh KI. (2016). DNA Demethylation of the Foxp3 Enhancer Is Maintained through Modulation of Ten-Eleven-Translocation and DNA Methyltransferases. Mol. Cells. 39(12):888-897. [PMID: 27989104]
- Xiaotian Zhang#, Jianzhong Su#, Mira Jeong#, Myunggon Ko, Yun Huang, Hyun Jung Park, Anna Guzman, Yong Lei, Yung-Hsin Huang, Anjana Rao, Wei Li, Margaret A Goodell. (2016). DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells. Nat. Genet. 48(9):1014-23. [PMID: 27428748]
- Sara Motagner, Cristina Leoni, Stefan Emming, Giulia Della Chiara, Chiara Balestrieri, Iros Barozzi, Viviana Piccol, Susan Tougher, Myunggon Ko, Anjana Rao, Cioacchino Natoli, Silvia Monticelli. (2016). TET2 regulates mast cell differentiation and proliferation through catalytic and non-catalytic activities. Cell Reports 15: 1566-1579.[PMID: 27160912]
- Jungeun An, Edahí González-Avalos, Ashu Chawla, Mira Jeong, Isaac F. López-Moyado, Wei Li, Margaret A. Goodell, Lukas Chavez*, Myunggon Ko*, Anjana Rao*. (2015). Acute loss of TET function results in aggressive myeloid cancer in mice. Nat. Comm. 6: 10071. [PMID: 26607761] (*co-corresponding authors)
- Myunggon Ko*, Jungeun An, Anjana Rao. (2015). DNA methylation and hydroxymethylation in hematologic differentiation and transformation. Curr. Opin. Cell Biol. 37: 91-101. [PMID: 26595486] (*corresponding author)
- Jae-A Han, Jungeun An, Myunggon Ko. (2015). Functions of TET proteins in hematopoietic transformation. Mol. Cells 38: 925-935. [PMID: 26552488]
- Evisa Gjini, Marc R. Mansour, Jeffry D. Sander, Nadine Moritz, Ashley T. Nguyen, Michiel Kesarsing, Si Chen, Myunggon Ko, You-Yi Kuang, Song Yang, Yi Zhou, Leonard I. Zon, J. Keith Joung, Anjana Rao, A. Thomas Look. (2015). A zebrafish model of myelodysplasia produced through tet2 genomic editing, Mol. Cell. Biol. 35: 789-804. [PMID: 25512612]
- Myunggon Ko#, Jungeun An#, William A. Pastor, Sergei Koralov, Klaus Rajewsky, Anjana Rao. (2015). TET proteins and 5-methylcytosine oxidation in hematological cancers. Immunological Reviews 263: 6-21. [PMID: 25510268] (#co-1st)
- Jeong M, Sun D, Luo M, Huang Y, Challen GA, Rodriguez B, Zhang X, Ko M, Wang H, Chen R, Gunaratne P, Godley LA, Darlington GJ, Rao A, Li W, and Goodell MA. (2014). Large conserved domains of low DNA methylation maintained by 5-hydroxymethycytosine and Dnmt3a, Nat. Genet. 46: 17-23. [PMID: 24270360]
- Myunggon Ko#, Jungeun An#, Hozefa S. Bandukwala, Lukas Chavez, Tarmo Äijö, William A. Pastor, Matthew F. Segal, Huiming Li, Kian Peng Koh, Harri Lähdesmäki, Patrick G. Hogan, L. Aravind, Anjana Rao. (2013). Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX, Nature 497:122-126. [PMID: 23563267] (#co-1st)
- Masato Sasaki, Christiane B. Knobbe, Momoe Itsumi, Andrew J. Elia, Isaac S. Harris, Iok In Christine Chio, Rob A. Cairns, Susan McCracken, Andrew Wakeham, Jillian Haight, Annick You Ten, Bryan Snow, Takeshi Ueda, Satoshi Inoue, Kazuo Yamamoto, Myunggon Ko, Anjana Rao, Katharine E. Yen, Shinsan M. Su, and Tak Wah Mak. (2012). D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function, Genes Dev. 26: 2038-2049. [PMID: 22925884]
- Jinwook Choi#, Myunggon Ko#, Shin Jeon, Yoon Jeon, Kyungsoo Park, Changjin Lee, Ho Lee, and Rho H. (2012). The SWI/SNF-like BAF complex is essential for early B cell development, J. Immunol. 188: 3791-3803. [PMID: 22427636] (#co-1st)
- Myunggon Ko and Anjana Rao. (2011). TET2: epigenetic safeguard for HSC, Blood 118: 4501-4503. (Commentary) [PMID: 22033942]
- Myunggon Ko#, Hozefa S. Bandukwala#, Jungeun An, Edward D. Lamperti, Elizabeth C. Thompson, Ryan Hastie, Angeliki Tsangaratou, Klaus Rajewsky, Sergei B. Koralov, and Anjana Rao. (2011). Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice, Proc. Natl. Acad. Sci. USA 108: 14566-14571. (*equally contributed) [PMID: 21873190] (#co-1st).
- William A. Pastor#, Utz J. Pape#, Yun Huang#, Hope R. Henderson, Ryan Lister, Myunggon Ko, Erin M. McLoughlin, Yevgeny Brudno, Sahasransu Mahapatra, Philipp Kapranov, Mamta Tahiliani, George Q. Daley, X. Shirley Liu, Joseph R. Ecker, Patrice M. Milos, Suneet Agarwal & Anjana Rao. (2011). Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. Nature 473, 394–397. [PMID: 21552279]
- Jeongeun Ahn#, Myunggon Ko#, Changjin Lee, Jieun Kim, Hana Yoon, and Rho H.Seong. (2011). Srg3, a mouse homolog of BAF155, is a novel p53 target and acts as a tumor suppressor by modulating p21WAF1/CIP1 expression. Oncogene 30: 445-456. [PMID: 20935679] (#co-1st)
- Myunggon Ko#, Yun Huang#, Anna M. Jankowska, Utz J. Pape, Mamta Tahiliani, Hozefa S. Bandukwala, Jungeun An, Edward D. Lamperti, Kian Peng Koh, Rebecca Ganetzky, X. Shirley Liu, L. Aravind, Suneet Agarwal, Jaroslaw P. Maciejewski& Anjana Rao. (2010). Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature 468: 839-843. [PMID: 21057493] (#co-1st)
- Myunggon Ko, Dong H. Sohn, Heekyoung Chung, Rho H. Seong. (2008). Chromatin remodeling, development and disease, Mut. Res. 647: 59-67. (Review) [PMID: 18786551]
- Jaehak Oh, Dong H. Sohn, Myunggon Ko, Heekyung Chung, Sung H. Jeon, and Rho H. Seong. (2008). Baf60a interacts with p53 to recruit the SWI/SNF complex. J. Biol. Chem. 283: 11924-11934. [PMID: 18303029]
- Jeongeun Ahn#, Myunggon Ko#, Kyuyoung Lee, Jaehak Oh, Sung H. Jeon and Rho H. Seong. (2005). Expression of SRG3, a core component of mouse SWI/SNF chromatin-remodeling complex, is regulated by cooperative interactions between Sp1/Sp3 and Ets transcription factors. Biochem. Biophysic. Res. Comm. 338: 1435-1446. [PMID: 16288722] (#co-1st)
- Cheol Yi Hong, Ji Ho Suh, Kabsun Kim, Eun-Yeung Gong, Sung Ho Jeon, Myunggon Ko, Rho Hyun Seong, Hyuk Bang Kwon, and Keesook Lee. (2005). Modulation of androgen receptor transactivation by the SWI3-related gene product (SRG3) in multiple ways. Mol. Cell Biol. 25: 4841-4852. [PMID: 15923603]
- Myunggon Ko, Jiho Jang, Jeongeun Ahn, Kyuyoung Lee, Heekyoung Chung, Sung H. Jeon, and Rho H. Seong. (2004b). T-cell receptor signaling inhibits glucocorticoid-induced apoptosis by repressing the SRG3expression via Ras activation. J. Biol. Chem. 279: 21903-21915. [PMID: 15016814]
- Myunggon Ko, Jeongeun Ahn, Changjin Lee, Heekyoung Chung, Sung H. Jeon, Hee-Y. Chung, and Rho H. Seong. (2004a). E2A/HEB and Id3 proteins control the sensitivity to glucocorticoid-induced apoptosis in thymocytes by regulating the SRG3 expression. J. Biol. Chem. 279: 21916-21923. [PMID: 15016815]
- Chung H, Choi YI, Myunggon Ko, Seong RH. (2002). Rescuing developing thymocytes from death by neglect. J. Biochem. Mol. Biol. 35:7-18. (Review) [PMID: 16248964]
- Sunmi Han, Heonsik Choi, Myung-gon Ko, Young I. Choi, Dong H. Sohn, Joong K. Kim, Dongho Shin, Heekyoung Chung, Han W. Lee, Jae-B. Kim, Sang D. Park, and Rho H. Seong. (2001). Peripheral T cells become sensitive to glucocorticoid- and stress-induced apoptosis in transgenic mice overexpressing SRG3. J. Immunol. 167: 805-810. [PMID: 11441086]
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특허출원
- 출원번호: 10-2021-0095931 (고명곤, 변성준)
TET 발현 또는 활성 저해에 의한 비만 및 대사질환 억제